After the clinicians meeting it was felt that the benefits of replacement therapy for women still outweighed the possible side effects; furthermore such problems had been rare in our clinics. In eleven years in a busy clinic at Prince Henry’s Hospital, we have had only one case of hyperplasia and no cases of cancer of the endometrium. We investigate all women with irregular or excessive bleeding and refer them to gynaecologists, so it is unlikely that we would miss one.
If oestrogen is given in excessive doses, taken continuously or if progestogen is not given with it, conditions may be set up which may lead to cancer in certain women. But progestogen produces a period, thereby clearing out the lining of the uterus so it does not get abnormally built up by the constant stimulation of the oestrogen.
Oestrogen is like any other therapy; all patients must be assessed individually. It should not be withheld from those who need it, nor should it be used indiscriminately. We have definite rules and routines of therapy in our clinics, worked out in the interests of women’s safety and based on work done in much larger population studies than we can do in Australia. These will almost certainly be the views of any conservative, well-informed doctor you consult.
Hormones are only given to relieve symptoms, that is we do not follow the practice used some time ago, of giving oestrogens to all women after the menopause.
Not all women will take oestrogen. The endocrinologists who helped me set up the clinics in the first place had told me that if I wanted to give women oestrogens I would have to sell them back their periods or I would run into problems. How right they were. To those women who say, ‘But I don’t want my periods back’, I can only reply, ‘You can’t have your cake and eat it. You can’t have the hormones of your youth without the disadvantages if you want to take it safely.’
The benefits must be weighed up against the risks. We have regular guidelines:
• we use the lowest dose which relieves symptoms.
• the oestrogen is never given without regular administration of the other hormone, progestogen (present in the monthly cycle when young), following which a small bleed often occurs.
• every year we wean patients off therapy over a month or so, and then remove therapy altogether to see if symptoms return and whether or not they need further treatment.
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